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Healthy Body


BRCA Testing:
For those with a family history of breast cancer

October 2016
Picture
By Nancy Burger
Should I Get The BRCA Test?

I remember when I first saw the acronym “BRCA” and wondered if it was a stock ticker symbol or perhaps the name of a new activist group. I quickly realized that it represented something much more relevant to me and to all women. BRCA stands for Breast (“BR”) and Cancer (“CA”) and refers to human genes (little bits of code within the body’s cells) that help repair damage to our cells. When BRCA genes become mutated or altered to the point where they can no longer repair damage in other cells, then those cells with mistakes can ultimately become a cancerous growth.

A BRCA gene test is a blood test that checks for any mutations in the BRCA genes, of which there are two types: BRCA1, BRCA2 and many subtypes. If the test finds gene changes in either BRCA1 or 2 (termed a “positive” result), this means your risk of breast or ovarian cancer is higher, and that there may also be an increased risk that other cancers could develop. A “negative” result means that no harmful changes are detected in the genes. To be clear: a BRCA test does not test for cancer itself, just for changes in these genes.

BRCA testing is administered for people with a strong family history of breast or ovarian cancer. You might be at increased risk of having a BRCA gene mutation — and a candidate for BRCA gene testing — if you have a personal history of:


  • Two first-degree relatives with breast cancer, one of whom was diagnosed before age 50
  • Three or more first or second-degree relatives diagnosed with breast cancer at any age
  • Both breast and ovarian cancer among your first and second-degree relatives
  • A first-degree relative with cancer in both breasts
  • Two or more relatives with ovarian cancer
  • One relative with both breast and ovarian cancer
  • A male relative with breast cancer
  • Ashkenazi Jewish ancestry
 
Understandably, a BRCA test can cause worry and send our imaginations running wild. Therefore, if you decide to have the test, you should meet with a genetic counselor before and after to better understand the benefits, risks and possible outcomes. If your test is positive, a counselor’s support can help you make informed medical and lifestyle decisions.
 
What should I do if I get a positive result?
 
You should talk to a genetic counselor to understand your options, which may include preventative measures such as:
 
  • Getting a clinical breast exam at regular intervals
  • Having a yearly mammogram alternating with an MRI (so one test every 6 months)
  • Undergoing preventative mastectomy (removal of all breast tissue)
  • Planning to have children before age 30, if possible
  • Having your ovaries removed after having children or after age 35
  • Taking a “chemo-preventative” medication such as Tamoxifen or another estrogen receptor antagonist
 
According to the National Cancer Institute, approximately 12% of women in the general population will develop breast cancer sometime during their lives, while 1.3% will develop ovarian cancer. Most recent estimates indicate that 55% to 65% of women who inherit a harmful BRCA1 mutation and 45% of those who inherit a similar BRCA2 mutation will develop breast cancer by age 70. About 39% of women who inherit a harmful BRCA1 mutation and 11% to 17% of those who inherit a harmful BRCA2 mutation will develop ovarian cancer by age 70.
 
Should I get tested even if I don’t meet the high-risk criteria?

For women whose families do not have risk factors for BRCA mutations, a genetic test is not likely to give any useful information about their chance of developing breast cancer. Women from average-risk families rarely have a positive test outcome. It is possible for a BRCA gene test to give a false-positive test result, so it is not recommended for a person without risk factors.

You can talk to your primary care doctor or gynecologist to determine whether or not a meeting with a genetic counselor is indicated or would be helpful to you. Most major breast centers have at least one designated person who can assess your risk and counsel you for testing. However, as is the case with many medical procedures, first make sure you’re informed and understand the meaning of different possible test results.

For more information:

www.mayoclinic.org
www.cancer.gov

​NEWS...

January Themes:
Hope, Reinvention,
No More Winter Blues


Next newsletter goes out:
February 3rd
​
Next Coffee & Conversation:

February 15, 2023
How Attachment Styles Affect Relationships
​
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